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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14981 | Clobetasone butyrate | Glucocorticoid Receptor | |
Clobetasone butyrate, a synthetic glucocorticoid with topical anti-inflammatory activity, is effective in treating corticosteroid-responsive dermatoses, such as atopic dermatitis and psoriasis, especially within skin tis... | |||
T27172 | Difamilast | PDE | |
Difamilast is an inhibitor of phosphodiesterase IV. | |||
T7893 | Bepotastine | Bepotastine free base | Others , Histamine Receptor |
Bepotastine (Bepotastine free base) free base is a histamine 1 (H1) receptor antagonis. | |||
T6405 | Bepotastine Besilate | Talion,TAU 284,Bepreve,Bepotastine Beslilate | Histamine Receptor |
Bepotastine Besilate (TAU 284) is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7). | |||
T4966 | Ufenamate | Flufenamic acid butyl ester,Butyl flufenamate | Others |
Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases | |||
T2648 | Pimecrolimus | SDZ-ASM 981,ASM 981 | Others |
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri... | |||
T16792 | Rovazolac | ALX-101 | Liver X Receptor |
Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis. | |||
T3987 | Lotamilast | E6005,RVT-501 | PDE |
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis. | |||
T29096L | Vapitadine | R 129160 | Histamine Receptor |
Vapitadine is a non-sedative antihistamine compound that relieves itching caused by atopic dermatitis. | |||
T77369 | Telazorlimab | ISB-830,GBR-830 | Immunology/Inflammation related |
Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells. Telazorlimab can be used to treat lupus erythematosus and atopic dermatitis. | |||
T6S0232 | Eriodictyol | Huazhongilexone | Influenza Virus , DNA/RNA Synthesis , Nrf2 , Endogenous Metabolite |
1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3.... | |||
T75113 | GLPG2534 | GLPG-2534 | IRAK |
GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis. | |||
T76775 | Fezakinumab | ILV 094 | Interleukin |
Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related conditions such as psoriasis, rheumatoid arthritis and atopic dermat... | |||
TN1236 | 3',4',7-Trihydroxyisoflavone | MAPK , JNK | |
3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radical scavenging properties.3',4',7-Trihydroxyisoflavone enhan... | |||
T76724 | Nemolizumab | CIM331 | Interleukin |
Nemolizumab (CIM331) is a humanized monoclonal antibody against human interleukin-31 receptor A that inhibits the binding and subsequent signal transduction of interleukin-31 (IL-31) to its receptor. Nemolizumab can be u... | |||
T2270 | Trans-Tranilast | Tranilast trans- | RAAS |
Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993.... | |||
T2392 | Nafamostat mesylate | FUT-175 | Apoptosis , Serine/threonin kinase , SARS-CoV , Serine Protease |
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. | |||
T13666 | Dupilumab | REGN-668,SAR-231893 | IL Receptor |
Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and... | |||
T76704 | Tralokinumab | CAT-354,LP 0162 | IL Receptor |
Tralokinumab is a fully human IgG4 monoclonal antibody with a high affinity for IL-13 alone. Tralokinumab's potential anti-inflammatory activity prevents IL-13 receptor interaction and subsequent downstream signaling and... | |||
T76884 | Spesolimab | BI 655130 | IL Receptor |
Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the immune system and is associated with a reduction in biomarkers associated with congenital Th1/Th17 and neutrophil p... |